Polycystic Ovary Syndrome (PCOS) is one of the most common hormonal disorders among women of reproductive age.Therefore, the current study was performed to discover out the effect of low carbohydrate diet ((LCD) and anise herb on PCOS - caused by the administered of letrozole (1 mg/kg p.o.) for 21 days in female rats. The results showed a significant decline (p<0.05) in body weight gain (BWG), changes in BWG % of PCOS rats feeding on LCD alone and the supplemented-LCD with anise, compared to that fed on the basal diet (BD) alone and the supplemented-BD with anise. In comparison to the positive control group, PCOS-rats fed on the either LCD alone or the supplemented-BD or -LCD with anise have significant (P < 0.05) amelioration in the serum levels of blood glucose, TC, TG, TL, LDL-c, VLDL-c, HDL-c, as well as insulin, luteinizing, follicle stimulating, testosterone, estradiol, progesterone, ehydroepiandrosterone sulfate and prolactin hormones, and activates of antioxidant enzymes (CAT, SOD, GSH and GPx). A better improvement in serum levels of the above parameters and histopathology examination of the ovary was discovered at feeding PCOS-rats on LCD alone or supplemented-LCD with anise, compared to the other groups. Finally, the ability of LCD and anise to enhance the treatment of PCOS degeneration makes it a hopeful natural diet and herb for the management of PCOS.