Purpose of study: Coronavirus disease 2019 (COVID-19) is a newly discovered respiratory disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and recently declared as pandemic. Mild to moderate symptoms are the initial presentation in most patients. Kidney damage is a frequent side effect of COVID-19. Acute phase reactants (APRs), are inflammation biomarkers that exhibit marked changes in blood concentrations at the time of inflammation. Important APRs include serum ferritin, C-reactive protein (CRP) and D-dimer. This study aimed to assess the role CRP and kidney function tests in Covid-19 and their impact on disease severity.

Basic procedures: This study was conducted on 80 subjects including 20 apparently healthy individuals (group II) as a control group matched for age and sex and 60 Covid-19 patients diagnosed by PCR (group I) and was subdivided into 2 subgroups, G Ia: 30 (Non- ICU) Covid-19 patients and G Ib: ICU (intensive care unit) admitted COVID-19 patients with respiratory complications. This study was conducted at clinical pathology department, faculty of medicine, Minia University during the period from November 2021 to June 2022.

Main findings: results of this study revealed a significant difference regarding CRP and kidney function tests as covid-19 patients showed higher levels than control group, but there was no significant difference between both patient groups. Principle conclusion: Overall, this study revealed that elevation of both CRP and kidney function tests indicate a poor prognosis in individuals with covid-19, therefore, they may be involved in prediction of clinical course of the infection.