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Effect of Lymphoma Treatment on Development of New Onset Diabetes

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Last updated: 09 Mar 2025

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Abstract

Background: Lymphoma, a heterogeneous malignancy of lymphocytes, is commonly treated with chemotherapy regimens like R-CHOP, which include glucocorticoids known to induce hyperglycemia and potentially cause new-onset diabetes or worsen existing diabetes. This study aimed to evaluate the effect of lymphoma treatment on the development of new-onset diabetes and related complications.


Methods: This observational cohort study included 61 lymphoma patients: 39 non-diabetic and 22 diabetic. Detailed history, physical exams, and lab investigations (FBS, 2-hour postprandial blood sugar, and HbA1c) were conducted before and after treatment.


Results: In the non-diabetic group, 23.1% developed new-onset diabetes. These patients had higher mean weight (85 ± 8 kg vs. 79 ± 7 kg, P = 0.046) and BMI (28.5 ± 3.2 vs. 23.4 ± 1.7, P < 0.001). Post-treatment, fasting blood sugar increased (123 ± 20 mg/dL vs. 90 ± 10 mg/dL, P < 0.001), as did 2-hour postprandial blood sugar (179 ± 31 mg/dL vs. 138 ± 16 mg/dL, P = 0.003) and HbA1c (5.9 ± 0.4% vs. 5.1 ± 0.3%, P < 0.001). BMI increase significantly predicted new-onset diabetes (OR = 1.984, 95% CI = 1.205–3.267, P = 0.007). In the diabetic group, 72.7% experienced complications, with higher post-treatment HbA1c levels (8.4 ± 0.7% vs. 7.5 ± 1%, P = 0.033) and more complications in those treated with R-CHOP (87.5% vs. 33.3%, P = 0.025).


Conclusions: Lymphoma treatments, especially those with steroids like R-CHOP, significantly increase the risk of new-onset diabetes and related complications, necessitating careful glucose monitoring and management.

DOI

10.21608/ejhbmt.2023.415978

Keywords

Lymphoma, Chemotherapy, R-CHOP, New-onset diabetes

Authors

First Name

Maha

Last Name

Mohamed

MiddleName

AA.

Affiliation

Internal Medicine Department, Faculty of Medicine, Benha University, Benha, Egypt

Email

eng.ahmed_zidan@yahoo.com

City

-

Orcid

-

First Name

Medhat

Last Name

Elamawy

MiddleName

M.

Affiliation

Internal Medicine Department, Faculty of Medicine, Benha University, Benha, Egypt.

Email

m.elamawy@fmed.bu.edu.eg

City

-

Orcid

-

First Name

Yasmin

Last Name

Marei

MiddleName

M.

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Benha University, Benha, Egypt.

Email

yasmin.marei@fmed.bu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Mohamed

MiddleName

A.

Affiliation

Internal Medicine Department, Faculty of Medicine, Benha University, Benha, Egypt.

Email

moh_tahar.haem@yahoo.com

City

-

Orcid

-

First Name

Hiam

Last Name

Eleleimy

MiddleName

AM.

Affiliation

Internal Medicine Department, Faculty of Medicine, Benha University, Benha, Egypt.

Email

hiameleimy@gmail.com

City

-

Orcid

-

Volume

10

Article Issue

11

Related Issue

40878

Issue Date

2023-04-01

Receive Date

2025-03-06

Publish Date

2023-04-01

Page Start

11

Page End

15

Print ISSN

2356-9735

Online ISSN

3009-7754

Article File

EJHBMT_Volume 10_Issue 11_Pages 11-15.pdf

PDF . 274.0kB

Link

https://ejhbmt.journals.ekb.eg/article_415978.html

Detail API

http://journals.ekb.eg?_action=service&article_code=415978

Order

415,978

Type

Original Article

Type Code

726

Publication Type

Journal

Publication Title

Egyptian Journal of Hematology and Bone Marrow Transplantation

Publication Link

https://ejhbmt.journals.ekb.eg/

MainTitle

Effect of Lymphoma Treatment on Development of New Onset Diabetes

Details

Type

Article

Created At

09 Mar 2025