Phosphotungstic acid (PWA) supported on MCM-41 coated nickel ferrite was prepared by impregnation of PWA. The samples have been characterized using X-ray analysis (XRD), Fourier Transform Infrared Spectroscopy (FT-IR) and Transmission Electron Microscopy (TEM). Acidity has been measured by using non-aqueous potentiometric titration of n-butylamine in acetonitrile and catalytic activity has been examined in synthesis of xanthene. The results indicated that the pore structure of MCM-41 was an ordered hexagonal and changed into spherical in MCM-41 coated nickel ferrite. The results showed also that there was an excellent dispersion of PWA on MCM-41 coated nickel ferrite surface. The acidity measurements indicated that the acidity and catalytic activity sharply increase by adding nickel ferrite and PWA to MCM-41.The sample doped with 55 wt. % PWA/MCM-41 coated nickel ferrite measures the highest surface acidity (592.4mV) with catalytic conversion reached to (94.7%). The catalysts can be separated from the reaction mixture by using a magnet.