Flexible thin films of 80w t% carboxymethyl cellulose (CMC) 20 wt% Polyvinylpyrrolidone (PVP) with copper oxide (CuO) variable mass fraction dopant were successfully synthesized. The effect of dopant CuO concentration was studied on correlation to the roughness parameters and swelling rate behavior of the studied nanocomposite. All doped samples were compared to their parent undoped polymeric blend of CMC/PVP. Obtained data shows the concentration dependence on the studied sample physical parameters. Studied samples characteristics suggest possible use in different medical, catalytic and optical applications.