New [Ni(curarg)(H₂O)₃].5H₂O chelate of curcumin arginine Schiff base have been synthesized  via  template reaction. The structure of the new complex was fully elucidated by various techniques such as elemental (CHN) analyses, FT-IR and UV-visible spectroscopies. Moreover, molar conductance and magnetic measurements were also carried out. TG and DTG thermal measurements were performed. Thermodynamic and kinetic parameters of the studied complex were discussed utilizing Coats-Redfern and Horowitz-Metzger equations. Finally, the antimicrobial studies of the tested complex were also evaluated