The most prevalent endocrine condition is hypothyroidism. There is disagreement over the occurrence of hypothyroid neuropathy and the nature of its etiology. To evaluate the affection of subclinical motor or sensory peripheral nerve among hypothyroid subjects. A total of 60 hypothyroid cases with no neurological symptoms were included and 60 healthy individuals were considered as controls. All subjects were investigated for medical history, full general and neurological examination, radiological and laboratory assessments and neurophysiologic nerve conduction study. Polyneuropathy was found mainly sensorimotor among 73.3% of the cases either axonal or demyelination affection. Sural and median nerves were the commonly affected nerves. Patients experienced a high rate of entrapment neuropathy, with carpal tunnel syndrome (CTS) accounting for 60%. In sensorimotor neuropathy, hypothyroidism is linked to polyneuropathy, primarily of the axonal affection type of motor nerve or demyelination affection in sensory neuropathy. Even in asymptomatic hypothyroid individuals, routine nerve conduction testing should be carried out early in the course of the disease to reduce the risk of structural damage and impairment.