Interstitial cystitis is a chronic disease that affects women mostly changing their lifestyle and affecting their ability to live a normal life. It is hard to diagnose as it intersects and comorbid with many diseases so the treatment of that disease is not easy.There are many theories about its pathogenesis ,one of which is oxidative stress. Experts observed anomalies in each subcellular layer of IC/ PBS patients' bladder tissue,some of it could be a result of lipid peroxidation due to high oxidive stress.Lipid peroxidation produces end-products such as malondialdehyde (MDA) which we will estimate to find the possible relationship between lipid peroxidation and IC.