Methylene blue dye is among the most popular dyes that have bad effects on aquatic life, so many efforts were directed to remove it from the environment. Our study aims to prepare a zirconium metal-organic framework called UiO-66 MOF to use it in the MB adsorption. (FTIR) and (SEM) were used how to describe the structural and microstructural the UiO-66 MOF. The prepared MOF revealed a significant adsorption capacity for MB reaching 70.29 mg/g. Researchers studied investigated how such parameters, including concentration, pH, temperature, weight and contact time altered the adsorption process. Meanwhile, the adsorption isotherms and kinetics were studied. The pseudo 2nd order kinetic and Langmuir adsorption isotherm models were found to be the most accurate descriptions of MB adsorption on the UiO-66 MOF.