The pyrazole nucleus is a special structural scaffold that makes a great and intriguing template for both material science and pharmaceutical chemistry. The present work presents a comprehensive review of the pharmaceutical applications of pyrazole and substituted pyrazole motifs, alongside the diversity of synthetic pathways showing how substances are synthesized. Additionally, it covers the most current studies and showcases the remarkably efficient synthetic approach as successful green chemistry resulting in accessing new pyrazole-bearing compounds in encouraging yields. The structural activity relationship (SAR), molecular docking, and ADMET for pyrazole derivatives were presented as a way to further demonstrate the interactions and safety of these compounds in biological systems in preparation for future drug development. This survey uncovers that pyrazole is an undeniable pharmacophore due to its huge benefits in restorative chemistry inquire about and other important areas of human endeavour.