Interstitial cystitis/bladder pain syndrome (IC/BPS), formerly known as interstitial cystitis, is chronic pelvic pain (lasting more than 6 weeks) with symptoms of discomfort, pressure or pain affecting or related to the bladder urinary. The disease is characterized by chronic inflammation and symptoms of the lower urinary tract that are not due to infection or other identifiable causes. Because IC/BPS remains a diagnosis of exclusion, this condition is often underdiagnosed or misdiagnosed. therefore we aim to study The role of oxidative stress in the development of IC/BPS by determination the level of the oxidative markers and it was measured by spectrophotometric assays in serum such as: Malondialdhyde (MDA) (lipid peroxidation marker), Protein carbonyl (PC) (protein oxidation marker) and nitric oxide (antioxidant marker) and then Statistical analysis was performed in order to correlate the level of the measured parameters with the development of IC/BPS  in women. Finally, we found an increase in NO, PC serum level of IC patients And there is no significant difference in MDA level in non ulcerative IC compared with the healthy group.