Background: Nephrotic syndrome is primarily a paediatric disorder and is 15 times more common in children than adults. Aims and Objectives: To  study  the  derangement  of  serum  lipid  profile  in children 2 to 12 years with  nephrotic  syndrome Subject and methods: The present study was a prospective observational pilot study on children with NS from Nephrology Unit of Mansoura University Children's Hospital (MUCH) over the years 2022 & 2023. The study included Nephrotic syndrome (NS) patients submitted to glucocorticosteroid treatment as a first line therapy.  Lipid Profile was measured. our results we concluded that nephrotic syndrome had generalised hyperlipidemia and abnormal lipid profile occur mostly among cases with SRNS