Evaluating the impact of feeding fermented jojoba meal (FJM) as a plant protein source on growth performance, feed consumption, serum biochemicals, and haematological variables was the goal of the study. Five different levels of plant protein sources (jojoba meal) fermented with Saccharomyces cerevisiae yeast (20%, 40%, 60%, and 80%) were fed to Nile tilapia. One of the five diets, T1, was a control diet without FJM, and the other four diets were designed to include FJM as follows: {T2 (20% FJM), T3 (40% FJM), T4 (60% FJM), and T5 (80% FJM)}. According to the results, the FBW, WG%, DWG, FE, and SGR values of the fish fed diets T1 (control), T2, and T3 were considerably (P<0.05) higher. However, the T5 had the lowest values compared to other group. The survival rate (SR%) of fish fed diets showed high rates of 97.77% in treatments T1 and T3, but there are no significant differences in this regard. Furthermore, there was no significant difference in tilapia fish FI, FCR, PER, or PPV% between groups. The outcomes demonstrated improvements in hematological and blood biochemical indices during therapy as compared to control. As a result, FJM is advised at a level of T2 (20% FJM) and T2 (20% FJM) diet, with no adverse effects on Nile tilapia fish growth performance, feed utilization, or blood health of Nile tilapia fish.