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413070

Oocyte and Embryo Qualities in Different Stimulation Protocols in IVF/ICSI Cycles: A Retrospective Study

Article

Last updated: 25 Feb 2025

Subjects

-

Tags

4. Reproductive Medicine / Minimal Acess Surgery

Abstract

Background: Worldwide, ovarian stimulation for Intracytoplasmic Sperm Injection (ICSI) uses GnRH analogues, agonists, and antagonists. They control pituitary activity to prevent LH surges and optimize oocyte retrieval. The consequences of advances on oocyte quality and embryo development are uncertain. GnRH agonists desensitize pituitary GnRH receptors gradually, while antagonists immediately decrease gonadotropin release. Oocyte and embryo quality and development, as well as mother age, hormonal condition, and infertility duration, have been examined to affect ICSI success.
Objectives: To examine the effects of the multiple-dose GnRH antagonist protocol on egg, embryo, and embryo development in IVF/ICSI cycles compared to the long protocol.
Patients and Methods: Two hundred and thirty two patients were included in this retrospective study. It was conducted in Division of Assisted Reproduction, Department of Obstetrics and Gynecology, South Valley University, Tanta University, and private centers. It included patients in the period from July 2017 to December 2022. Patients' data, stimulation protocols, oocytes and embryo qualities were assessed and pregnancy rates. Patients were allocated according to stimulation protocol into agonist and antagonist groups. Data were gathered and analyzed.
Results: Basal demographic data of both groups was comparable. Gonadotropins dose in both groups were 3899.26 ± 1363.99 IU/ml in antagonist group versus 3737.69 ± 932.26 IU/ml in agonist group (p=0.287). Oocytes numbers, and quality of oocytes were better in agonist protocol but the differences were not significant. Stimulation duration was negatively correlated. Embryo quality was comparable in both groups (p=0.681).
Conclusion: The GnRH agonist regimen had increased mature oocytes with good quality oocytes but differences not reaching clinical significance. Fertilization rates and embryo parameters were similar, however stimulation duration significantly affected oocyte and embryo quality.

DOI

10.21608/ebwhj.2024.290448.1325

Keywords

Anti-Mullerian hormone, GNRH agonist, GnRH antagonist, Embry, oocytes

Authors

First Name

Mostafa

Last Name

Khodry

MiddleName

Mohamed

Affiliation

Obstetrics and gynecology qena , south valley university

Email

khodrymesh@yahoo.com

City

-

Orcid

-

First Name

Ayman

Last Name

Dawood

MiddleName

-

Affiliation

Department of Obstetrics and gynecology, Tanta university

Email

ayman.dawood@med.tanta.edu.eg

City

-

Orcid

0000-0002-6607-5828

First Name

Heba

Last Name

El basiuny

MiddleName

-

Affiliation

Tanta univerity

Email

hebarady@hotmail.com

City

Tanta

Orcid

-

Volume

15

Article Issue

15

Related Issue

52902

Issue Date

2025-01-01

Receive Date

2024-05-17

Publish Date

2025-01-01

Page Start

1

Page End

9

Print ISSN

2090-7265

Online ISSN

2090-7257

Link

https://ebwhj.journals.ekb.eg/article_413070.html

Detail API

http://journals.ekb.eg?_action=service&article_code=413070

Order

413,070

Type

Original Article

Type Code

366

Publication Type

Journal

Publication Title

Evidence Based Women's Health Journal

Publication Link

https://ebwhj.journals.ekb.eg/

MainTitle

Oocyte and Embryo Qualities in Different Stimulation Protocols in IVF/ICSI Cycles: A Retrospective Study

Details

Type

Article

Created At

25 Feb 2025