This survey was applied to 50 marine fish samples of the greasy grouper Epinephelus tauvina collected randomly from Safaga City in the Red Sea province. Infected fish showed no obvious clinical abnormalities except attachment of isopod to the skin. Internally, some fishes showed paraniza in the buccal cavity and gills.  Other fishes showed dark grayish encapsulated plerocercoid or larvae of philometra in the abdominal cavity and internal organs. The infection rate and intensity of isopods, Praniza larvae, Philometra spp., and Trypanorhyncha sp. from Epinephelus tauvina were 4% & 1/fish, 28% & 3-7/fish, 32% & >20/fish, and 23% & 3-9/fish, respectively. Abundant mixed parasitic infections implicating Argathona isopods, Praniza larvae of Gnathiids, Philometrid nematodes, and Trypanorhynch larval cestodes, were frequently seen. A morphological description of the structure and characteristics of each isolate was performed. Isolated parasites were identified using optical and electron microscopy to analyze the specimens' morphology. The histopathological alterations in tissues of naturally infected fishes induced by isolated parasites on different organs were described.