The aim of this study was to investigate the ant-osteoporosis and obesity effects of Chia seeds powder. 25 female rats each weighting170 ±5 g was apportioned to five groups. The first group is the negative control group was fed a standard diet while the other groups were given a high-fat diet and injection by dexamethasone (7mg/kg b. wt) once a week for up to four weeks to induce obesity and osteoporosis. The osteoporosis and obese rats were classified into four groups, the positive control group was kept untreated, while three other groups received chia seed treatments at 3%, 6%, and 9% levels in diet for 60 days. This study resulted showed that all treated groups significantly improved their BWG, BWG%, feed intake, FER, BMI, parathyroid hormone (PTH), calcium and phosphorus serum, CH, TG, LDL, VLDL, bone mineral density (BMD) and bone mineral concentration (BMC). They are also all significantly increased their calcitonin and HDL levels. Our findings show that powdered chia seeds can reduce obesity and osteoporosis risk factors..