The aim of this study was to investigate the effects of soy protein diet (SD) and mixture between (SD) and Casein (1:1 w/w), supplemented with 5% from cardamom (Car), green coffee (GC), and olive leaves (OL), or a or 5% mixture from them, on daily feed intake (FI), body weight gain % (BWG%), organ weights / body weight % (OW / BW%), kidney functions , and histopathological changes of  kidneys in acute renal failure rate (ARFR). A total of 78 adult male albino rats of the Spragu-Dawley strain, weighing 200±10 g, were used in this study. The rats were divided into two main groups. The first main group (6 rats) was fed a basal diet (BD) and used as a control negative group (-ve). The second main group (72 rats) was injected with glycerol to induce acute renal failure. These rats were divided into 12 subgroups; one of them (6 rats) was fed on BD used as the (+ve ) control group . The other subgroups (11 subgroups) were fed on (SD) or (BD) or mixed protein (1:1) from soybean and casein, supplemented with 5% from (Car), (GC), (OL) or (5%) mixture between them for 8 weeks. At the end of the experiment, rats were anesthetized with ether before being sacrificed after fasting overnight. Kidneys were then removed and weighted. Blood samples were collected, left to clot, and then serum was separated. The serum uric acid, urea nitrogen, and creatinine levels were determined, and the kidneys were examined for histopathological changes. The obtained results revealed that glycerol injection-induced acute renal failure led to a non-significant change in FI while induced a significant decrease in BWG % as compared to the (-ve) control group. The obtained results revealed that diets containing treatments for rats suffer from ARF. Soybean protein, BD, supplemented with Car, GC, or OL, induced a significant improvement in all parameters. Meanwhile, the positive groups fed a diet containing a mixture of 50% protein from soybean and 50% casein, supplemented with a 5% mixture from (Car, OL, and GC showed the best improvement.  This diet led to a non-significant change in feed intake (FI) and a non-significant decrease in body weight gain percentage (BWG%) compared to the positive control group. The dietary treatment significantly decreased the relative weight of the kidney as well as levels of uric acid, urea nitrogen, and creatinine compared to the positive control group. Histopathological examination revealed changes in the kidneys of rats injected with glycerol, but most of these lesions were ameliorated following the dietary treatments, compared to the positive control group fed only the basal diet (BD). In conclusion, the mixture of soybean and casein (1:1) supplemented with a 5% blend of Car, OL, and GC contains a considerable number of healing compounds, namely polyphenols, flavonoids, and isoflavonoids. These compounds can help protect against kidney toxicity and are valuable for dietary therapy in the treatment of acute renal failure.