Abstract: Background: Peri-menopause constitutes a major transition point in women's reproductive and psychological life. Purpose: examine the effect of application of Roy adaptation model on coping with peri- menopausal symptoms among employed women. Design: Quasi experimental design was used. Setting: Study was conducted at Menoufia university administrative building, Menoufia governorate Egypt. Subjects: A purposive sample of 100 administrative employed women at menopausal age (45-55 years) who working in administrative building. Instruments: Socio-demographic & Reproductive Characteristics Questionnaire, Menopausal Rating Scale, Roy Adaptation Model Scale. Results: statistically significant difference regarding to grand total levels of menopause rating scale between pre & post-intervention, high significant negative correlation between post intervention total score of Roy Adaptation behavior and total score of menopausal symptoms (r = -0. 44, p<0. 0001) among peri- menopausal employees' women. Finally, post-intervention program revealed a highly significant improvement (p<0. 000) in the percentages of “Effective Adaptation behavior" responses, in each of the four subunits: Physiological mode, self-concept mode, Role function mode and Interdependence mode. Conclusion: Application of Roy adaptation model has positive consequences on improving women's coping ability regarding peri-menopausal period and its related risk factors. Recommendation: raising awareness about menopause symptoms through ensuring that appropriate health information and services are available to women to promote healthy aging and good quality of life before, during and after menopause.