This study investigated the effects of a high-fat diet with varying levels of date palm pith (palmetto) (5%, 10%, and 15%) on rats with induced diabetic nephropathy. Thirty-five rats were divided into five groups (n=7 each): Group 1 was fed a standard diet and served as the negative control; Group 2 consisted of obese rats with diabetic nephropathy fed a high-fat diet, serving as the positive control; Groups 3 to 5, like Group 2, were fed a high-fat diet but with the addition of dried palm date pits at 5%, 10%, and 15%, respectively. Results indicated that adding palmetto at these levels significantly (P<0.05) increased final body weight, feed intake, and body weight gain percentage compared to the positive control group. Additionally, rats treated with palmetto exhibited a significant increase (p<0.05) in insulin concentration, lower glucose levels, and elevated levels of catalase, as well as improvements in liver and kidney functions were also observed. These findings suggest that palmetto may have a therapeutic role in mitigating complications associated with diabetic nephropathy.