Background: Ewing sarcoma is a very aggressive malignancy tumor that requires complex multidisciplinary management. The aim of the study: Was to assess caregivers' awareness regarding health care offered to their children with Ewing sarcoma. Research design: A descriptive analytical design was utilized. Setting: The study was conducted at outpatient clinics for bone tumors in Elbuhaira cancer center, Egypt. Sample: convenience sample composed of (335) caregivers caring for their children with Ewing sarcoma. Tools: Three tools were used. First tool: Structured interviewing questionnaire for caregiver was used. Second tool: Attitude of caregiver for children with Ewing sarcoma. Third tool: Observational checklist for health status of child with Ewing sarcoma. Results: 66.2% of the studied caregivers had un satisfactory total level of knowledge, 57.7% of them had un satisfactory total level of reported practice, and 51.3% of them had a negative attitude. 80.3% of children with Ewing sarcoma had a high health needs. Conclusion: There were a highly statistical significant relation between caregivers' total knowledge and their educational level, monthly income, age, and relation with child. There was a highly statistical significant relation between caregivers' total knowledge and their total reported practice, and between caregivers' total reported practice and their total children health needs. Recommendations: Increasing awareness of the Caregiver about Ewing sarcoma through periodically educational programmers . Further studies including larger samples of children with Ewing sarcoma and their caregivers from different geographical areas to generalize the results in Egypt.