Back ground Depression is one of the most common complications in pregnancy. Prenatal depression not only affect women but also her fetus. So several professional organizations now recommend routine screening for antenatal depression. The aim: of this study is to assess prenatal screening for risk factors of depression during pregnancy. Research Design: the researcher used descriptive study design. Setting: This study was conducted at the antenatal clinic at Ain Shams University Maternity Hospital. Sample size: 500 pregnant women .Tools :two tools were used in this study 1- structured interviewing questionnaire sheet 2- Edinburgh prenatal depression scale Result: The results of the present study presented that 38.8%of the studied women has possible depression with associated the following risk factors (70.2%) of studied women not receive support with live stress, (53.6%) unplanned for the current pregnancy, 39.3% economic problems, 29.8% relation with others and  marital problems during current pregnancy with (40.4%) Conclusion: the study concluded that one third of the studied women have possible depression and the main risk factors for possible antenatal depression are the pregnant women who did not receive support for life stressors (more than two third of them) also about fifth of them their risk factors for developing prenatal depression was maternal problems during current pregnancy. Recommendation: Each pregnant woman should be screened for prenatal depression before childbirth and the hospital management should introduce screening for depression as part of routine antenatal assessments