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Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant And Molecular Docking Studies Of Polyfunctional Substituted Azoles, Azines, And Their Analogs Linked

Article

Last updated: 25 Feb 2025

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Subjects

-

Tags

Organic chemistry

Abstract

A new series of substituted azoles, azines, and their analogs linked sulfamethoxazole moiety was designed and synthesized. The antioxidant activity study of our synthesized compounds and molecular docking enhancement were achieved. Moreover, the antimicrobial assay indicated that compound 1 is the more active compound against all the stains compared to the reference drugs. So, reactions of β-oxobutanamide derivative 1 with different reagents afforded compounds 2a,b, 5, 7 and 8 12 and 14. Coupling of 1 with diazonium salt yield aryl hydrazones 10a,b which reacts with ethyl chloroformate to yield the triazinediones 11a,b. Reactions of enaminone 12 with some electrophilic and nucleophilic reagents to yield compounds 16, 21, 22, 23, 24 and 25 respectively. The structures of all compounds were characterized by means of spectral and elemental analyses.

DOI

10.21608/ejchem.2024.286549.9673

Keywords

Azoles, Azines, antioxidants, antibacterial agents, Molecular docking

Authors

First Name

ibrahim

Last Name

mousa

MiddleName

abdel-motaleb

Affiliation

Chemistry department-Faculty of science- South valley university- Qena - Egypt

Email

ibrahimchem@yahoo.com

City

Qena

Orcid

-

First Name

Awatef

Last Name

El-Maghraby

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, South Valley University, Qena 83523, Egypt

Email

awatef_elmaghraby@yahoo.com

City

Qena

Orcid

-

First Name

Abdallah

Last Name

Hassane

MiddleName

M. A.

Affiliation

Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Assiut

Email

abdallahhassane@azhar.edu.eg

City

asssiut

Orcid

-

First Name

Hatem

Last Name

Gaafar

MiddleName

-

Affiliation

national research center/EGYPT

Email

hatemgaafar197@gmail.com

City

-

Orcid

-

First Name

Muhammad

Last Name

Yahya

MiddleName

E.

Affiliation

Department of chemistry, faculty of science, south valley university

Email

ch.eltayeb@gmail.com

City

-

Orcid

0000-0002-6905-4782

First Name

Abdelhaleem

Last Name

Hussein

MiddleName

M

Affiliation

Department of Chemistry, Faculty of Science, Al Azhar University, Assiut 71524, Egypt

Email

abdelhaleemmh@yahoo.com

City

-

Orcid

-

Volume

68

Article Issue

3

Related Issue

53789

Issue Date

2025-03-01

Receive Date

2024-05-24

Publish Date

2025-03-01

Page Start

329

Page End

344

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 68_Issue 3_Pages 329-344.pdf

PDF . 1.5MB

Link

https://ejchem.journals.ekb.eg/article_373180.html

Detail API

http://journals.ekb.eg?_action=service&article_code=373180

Order

373,180

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant And Molecular Docking Studies Of Polyfunctional Substituted Azoles, Azines, And Their Analogs Linked

Details

Type

Article

Created At

15 Feb 2025