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Diagnostic, Prognostic, and Therapeutic Significance of Long Noncoding RNAs MALAT1 and UCA1 in Hepatocellular Carcinoma

Article

Last updated: 09 Mar 2025

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Subjects

-

Tags

Biochemistry

Abstract

Long non-coding RNAs (lncRNAs) are involved in the development and progression of many cancers, including hepatocellular carcinoma (HCC). This study investigates two specific lncRNAs, MALAT1 (Metastasis-associated lung adenocarcinoma transcript 1) and UCA1 (Urothelial carcinoma-associated 1), as potential biomarkers for early HCC diagnosis, prognosis, and therapy evaluation. The study included three groups: HCC patients treated with sorafenib (n=120), HCV patients (n=120), and healthy controls (n=120). MALAT1 and UCA1 expression levels were measured in serum using Real Time PCR, alongside routine clinical evaluations and investigations. MALAT1 and UCA1 levels in HCC patients were significantly higher than those in the HCV group (223.9 vs. 13 and 24.8 vs. 2.34, respectively; P < 0.001). MALAT1 and UCA1 demonstrated high diagnostic accuracy for HCC with cutoff values of 87.76 and 12, respectively. MALAT1 showed a sensitivity of 96.67% and specificity of 95.0%, while UCA1 had a sensitivity of 93.33% and specificity of 92.5%. In addition, elevated levels of MALAT1 and UCA1 were associated with poor survival rates and resistance to sorafenib treatment, observed in 90% and 80% of cases, respectively. In conclusion, MALAT1 and UCA1 are promising non-invasive biomarkers for the diagnosis and prognosis of HCC. Their elevated expression levels correlate with poor survival and resistance to sorafenib treatment, underscoring their potential as targets for lncRNA-based therapies.

DOI

10.21608/ejchem.2024.300940.9936

Keywords

HCC, LncRNAs, MALAT1, UCA1, Sorafenib

Authors

First Name

Shimaa

Last Name

Abdelsattar

MiddleName

-

Affiliation

Clinical biochemistry and molecular diagnostics department, National Liver Institute, Menoufia University.

Email

shimaa.abdelsattar@liver.menofia.edu.eg

City

-

Orcid

-

First Name

Ashraf

Last Name

Basuni

MiddleName

Abbass

Affiliation

Clinical biochemistry and molecular diagnostics department, National Liver Institute, Menoufia University.

Email

ashrabasuni50@gmail.com

City

CAIRO

Orcid

https://orcid.org/00

First Name

Eman S.

Last Name

Sawan

MiddleName

-

Affiliation

Department of Clinical Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr, Cairo 11828

Email

eman.said@buc.edu.eg

City

Badr University in Cairo (BUC), Badr, Cairo 11828

Orcid

-

First Name

Mona Gamal

Last Name

El-Abd

MiddleName

-

Affiliation

Clinical pathology department, National liver institute, Menoufia university

Email

m.elabd@liver.menofia.edu.eg

City

Menoufia

Orcid

-

First Name

Esraa Elsayed

Last Name

Abdel Maksoud

MiddleName

-

Affiliation

Medical microbiology and immunology department, Faculty of medicine, Menoufia University

Email

dr_esraa_elmahydy87@yahoo.com

City

Menofia

Orcid

-

First Name

Aliaa

Last Name

Sabry

MiddleName

-

Affiliation

Hepatology and gastroenterology department, National Liver institute, Menoufia university

Email

aliaasabry@liver.menofia.edu.eg

City

Menoufia

Orcid

-

First Name

Asmaa

Last Name

Mosbeh

MiddleName

-

Affiliation

Fellow at pathology department, National liver institute, Menoufia university

Email

asmaa.abdelmaksoud@osumc.edu

City

Menofia

Orcid

-

First Name

Sally Mohammed

Last Name

El-Hefnawy

MiddleName

-

Affiliation

Department of Basic medical science, faculty of dentistry, Alryada University for Science and Technology (RST), Sadat city, Egypt

Email

doctor_sally@rocketmail.com

City

Sadat city

Orcid

0000-0003-3090-0141

First Name

Ehab

Last Name

Darwish

MiddleName

-

Affiliation

Tropical Medicine department, Faculty of medicine, Zagazig University

Email

ehab_drwish_123@yahoo.com

City

Zagazig University

Orcid

-

First Name

Amira I.

Last Name

Aldesoky

MiddleName

-

Affiliation

Clinical oncology and nuclear medicine department, Faculty of medicine, Menoufia university

Email

amira.i.ahmed73@gmail.com

City

Shebin Elkom

Orcid

-

First Name

Alshimaa Mahmoud

Last Name

Elhanafy

MiddleName

-

Affiliation

Clinical oncology and nuclear medicine department, Faculty of medicine, Menoufia university

Email

alshimaa_alhanafy@yahoo.com

City

Shebin Elkom

Orcid

-

First Name

Hytham M.

Last Name

Ahmed

MiddleName

-

Affiliation

Pharmaceutical Analysis department, Faculty of Pharmacy, Menoufia university

Email

hmaahmed@menofia.edu.eg

City

Menofia

Orcid

-

First Name

Suzan M.

Last Name

El-Morshedy

MiddleName

-

Affiliation

Clinical pathology department, National liver institute, Menoufia university

Email

suzan.elmorshedy75@yahoo.com

City

Menoufia

Orcid

-

Volume

68

Article Issue

3

Related Issue

53789

Issue Date

2025-03-01

Receive Date

2024-07-03

Publish Date

2025-03-01

Page Start

539

Page End

550

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 68_Issue 3_Pages 539-550.pdf

PDF . 426.3kB

Link

https://ejchem.journals.ekb.eg/article_372803.html

Detail API

http://journals.ekb.eg?_action=service&article_code=372803

Order

372,803

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Diagnostic, Prognostic, and Therapeutic Significance of Long Noncoding RNAs MALAT1 and UCA1 in Hepatocellular Carcinoma

Details

Type

Article

Created At

15 Feb 2025