The current research aims to investigate the association between PPAR-γ genetic polymorphism at the rs1801282 loci and ischemic stroke risk in the Egyptian population. Method: The study included 100 individuals diagnosed with ischemic stroke and 150 age- and sex-matched healthy controls. DNA was extracted from peripheral blood samples prior to the detection of SNP genotyping via ARMS-PCR. The study found that CG and GG genotypes (CG vs. CC+GG) were more common in stroke groups compared to the control group (P = 0.001), which meant that people with these genotypes were more likely to have a stroke. However, there were no significant differences between the two groups of cases and controls for the recessive model (P > 0.05). No significant association was found regarding blood pressure, TG, or TC among stroke patients. Conclusion: The common polymorphism in PPARγ, rs1801282 C>G, increases the susceptibility to ischemic stroke in the Egyptian population. Further study of the association between the SNP and ischemic stroke is needed in larger studies.