Chronic kidney disease (CKD) in children is a devastating illness that has severe long-term negative outcomes to the well-being of affected children, as it severely worsens mortality and morbidity rates and deteriorates their quality of life. Accumulation of phosphate as a result of impaired renal function may induce kidney damage and accelerate CKD progression. Additionally, hyperphosphatemia may contribute to several CKD associated complications such as vascular diseases and hypertension. Therefore, we aim to study the association between progressive loss of renal function and phosphate levels in blood samples of our study group of children with CKD, in order to enhance our understanding to the correlation between hyperphosphatemia and compromised renal function