The cancer of the bladder (UBC) is the most prevalent site of cancer in the urinary system. UBC  is roughly three times more prevalent in males than in women, with the majority occurring in industrialized nations, but growing in emerging countries due to lifestyle changes. Few cytokines have an important role in cancer formation. Aim: to evaluate the role of interleukin 6, interleukin 12 and interleukin 1B as diagnostic and Prognostic Factors for UBC in Egyptian Patients. Methods: A case-control study included 100 patients with UBC and 100 healthy control participants. We used ELISA to measure the levels of IL 6, IL 12, and IL 1B in those patients and controls. Results: The UBC group had considerably higher median levels of IL-12, IL-1B, and IL 6 compared to the control group (p-value < 0.001), demonstrating a statistically significant relationship between these cytokines and UBC. Conclusion: High level of IL-6, IL-12 and IL1B were associated with an increased risk of UBC.