Pediatric Nephrotic syndrome, which is a condition affecting the kidneys, is more prevalent in children than in adults. Aims and Objectives: To investigate urine derangement in children aged 2-12 years with nephrotic syndrome. Patients and methods: The current study was a prospective observational pilot study on children with NS from "The Nephrology Unit of Mansoura University Children's Hospital (MUCH)." over the years 2022 & 2023. The study included Nephrotic syndrome (NS) patients who suggested glucocorticosteroid conduct as a first-line therapy. Urine examination was measured, to understand the relation between uremia and comprised renal function and develop the life quality for children grappling with CKD. Conclusions: Uremic toxins, including urea and creatinine, accumulate in the blood as kidney function declines. These toxins can have systemic effects and contribute to the progression of CKD