The illness known as interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by an overly sensitive bladder; usual causes are still unknown. The purpose of this study was to look into the association between the amounts of heavy metals Pb and Cd) in IC/BPS persons' blood and urine. Two groups of seventy Egyptian women were created: those with an IC diagnosis and healthy controls. The findings demonstrated that, in comparison to the control group, the blood and urine of IC patients had considerably higher amounts of Cd and Pb. Patients with IC were also found to have high cholesterol level. Even though they were still within in the normal range, IC patients had low levels of albumin and total protein. Urinary proteins did not substantially correlate with heavy metal levels in the blood or urine, while the protein / creatine ratio was significantly higher in IC patients than in the control group. According to this study, heavy metals may directly increase the risk of IC.