Abstract Background: Obstructive sleep apnea (OSA) is a prevalent chronic illness that influences around 2-4% of the adult people, with the greatest incidence observed in middle-aged patients. Aim of Study: To assess the influence of oropharyngeal training on sleep and oropharyngeal muscle activity within OSA cases. Patients and Methods: This study was a randomized con-trol trial carried outon 40 patients performed on both genders between the ages of 45 and 55 selected from Neurophysiolog-ical Department at El-Kasr El-Ani Hospital between August 2023 to August 2024. After clinical assessment, they were randomly categorized into 2 equal groups of twenty cases per group. The study was designed to evaluate the effect of oropharyn-geal muscle activity in obstructive sleep apnea patients. Results: Among group A, a statistically significant decline has been observed in Pittsburgh Sleep Quality Index (PSQI) after 12 weeks, from 8.6 before treatment to 4.8 after 12 weeks of resistance exercises and among group B, there was a statisti-cally significant decline in PSQI after 12 weeks, from 9 before treatment to 3.2 after 12 weeks of combined resistance exercis-es and OTP. Among group A, there was a statistically signifi-cant decline in ESS after 12 weeks, from 14.5 before treatment to 11.7 after 12 weeks of resistance exercises and among group B, there was a statistically significant decline in ESS after 12 weeks, from 14.3 before treatment to 10 after 12 weeks of com-bined resistance exercises and OTP. Conclusion: Our findings suggest that combined resistance exercises and oropharyngeal training are more effective in de-creasing day time sleepiness and enhancing sleep quality com-paring with resistance exercises alone in patients with OSA.