411324

Final Height in Patients with Congenital Adrenal Hyperplasia: The Controversy of Under Treatment Versus Overtreatment

Article

Last updated: 15 Feb 2025

Subjects

-

Tags

-

Abstract

Abstract Background: Growth patterns in congenital adrenal hyper-plasia (CAH) are challenging. Androgen excess can occur at any age leading to accelerated growth, early epiphyseal closure and compromised final height (FH). The FH in CAH is usually expected to be lower than predicted based on parental height or compared to the healthy population. Aim of Study: To evaluate growth and FH in patients with CAH. Patients and Methods: This retrospective study included 34 patients diagnosed with classic CAH (27 salt wasting and 7 simple virilizing). An anthropometric assessment was done for the patients and their parents to estimate the FH, target height (TH) and corrected FH (FH – TH). Therapeutic and biochemi-cal data were obtained from their clinical records. Results: FH and FH SDS were 161.35±6.56cm; -1.74 SD and 151.16cm; -1.46 SD in males and females respectively. FH showed more than 5cm reduction compared to TH (p<0.05). However, there was no significant difference between the cor-rected FH SDS and TH SDS in both sexes (p>0.05). Patients with SV CAH had worse FH and TH as well as their SDSs (p<0.05). Males with earlier onset of puberty had reduced FH (p<0.05). Mean androgen levels and glucocorticoid doses did not significantly impair FH in our patients (p>0.05). Conclusion: The corrected FH of our CAH patients, de-spite being lower than the normal population, was appropriate to their TH. FH was influenced by genetic potential in both sex-es as well as onset of puberty in males.

DOI

10.21608/mjcu.2024.411324

Keywords

Androgens, CAH, glucocorticoids, Height

Authors

First Name

RANA A.A. MAHMOUD, M.D.*; HEBA H. ELSEDFY, M.D.*; MOHAMMED K.E. ASHOUR, M.Sc.**;

Last Name

MOHAMED S. EL KHOLY, M.D.* and MARWA M.H. NAWAR, M.D.*

MiddleName

-

Affiliation

The Department of Pediatrics, Faculty of Medicine, Ain Shams* and Alexandria** Universities

Email

-

City

-

Orcid

-

Volume

92

Article Issue

12

Related Issue

53751

Issue Date

2024-12-01

Receive Date

2025-02-12

Publish Date

2024-12-01

Page Start

1,017

Page End

1,023

Print ISSN

0045-3803

Online ISSN

2536-9806

Link

https://mjcu.journals.ekb.eg/article_411324.html

Detail API

http://journals.ekb.eg?_action=service&article_code=411324

Order

411,324

Type

Original Article

Type Code

263

Publication Type

Journal

Publication Title

The Medical Journal of Cairo University

Publication Link

https://mjcu.journals.ekb.eg/

MainTitle

Final Height in Patients with Congenital Adrenal Hyperplasia: The Controversy of Under Treatment Versus Overtreatment

Details

Type

Article

Created At

15 Feb 2025