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411484

Synergistic Efficacy Study of Praziquantel and Ginger Alcoholic Extract as Antiparasitic in Vitro

Article

Last updated: 15 Feb 2025

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Subjects

-

Tags

Antimicrobial agents

Abstract

Background: Hydatid disease is a disease caused by the tapeworm Echinococcus, and the parasite can infect the liver, lungs, etc. This disease poses a health risk due to the serious complications that may occur from it. Objectives: The present study aimed to know the effect of each of: praziquantel, ginger alcoholic extract, in addition to niosome loaded with ginger extract, as well as the synergistic complex of praziquantel with niosome loaded with ginger extract, in eliminating the protoscolices of hydatid cysts in vitro. Metheology: After Preparation of alcoholic ginger extract and noisome loaded with it, the effects of different therapeutic compounds on the protoscole were tested using concentrations (5, 10, 20, 30, 50, 100, 150 mg/ml) of each extract, with incubation periods ranging from 5 to 60 minutes. Results: The results for the synergistic compound loaded with niosomal extract and ginger extract produced the highest extermination rate of 79% after 60 minutes. While, praziquantel extermination rate ranged from 66% to 79% and ginger extract at 5 mg/ml showed extermination ranging from 32% to 40%. Statistical tests reveal significant differences between treatments with ANOVA test results (F=11; p<0.00018) showing the high efficacy of the synergistic compound over praziquantel and ginger extract. Conclusion: The synergistic combination of niosome loaded with ginger extract and praziquantel showed high efficacy in vitro protoscolices extermination rates, but the standard deviation value of data analysis confirmed the presence of a state of instability. Niosome loaded with ginger extract showed excellent extermination efficacy with stable effects. Therefore, it is considered the best choice as a treatment. The extermination efficacy of praziquantel and ginger alcoholic extract was within the average values.

DOI

10.21608/ejmm.2025.349690.1428

Keywords

Hydatid disease, Synergistic, Therapeutic, praziquantel

Authors

First Name

Hiba

Last Name

Al-Abodi

MiddleName

R.

Affiliation

Department of Environment, College of Science, University of Al-Qadisiyah, Iraq

Email

hiba.al-abodi@qu.edu.iq

City

-

Orcid

0000-0001-9160-8318

First Name

Asifa

Last Name

Almaeahi

MiddleName

M.

Affiliation

Department of Biology, College of Education, University of Al-Qadisiyah, Iraq

Email

asifa.almaeahi@qu.edu.iq

City

-

Orcid

-

First Name

Marwa

Last Name

Alwan

MiddleName

S.

Affiliation

Department of Biology, College of Education, University of Al-Qadisiyah, Iraq

Email

marwa.alwan@qu.edu.iq

City

-

Orcid

-

Volume

34

Article Issue

3

Related Issue

53640

Issue Date

2025-07-01

Receive Date

2025-01-02

Publish Date

2025-07-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_411484.html

Detail API

http://journals.ekb.eg?_action=service&article_code=411484

Order

411,484

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Synergistic Efficacy Study of Praziquantel and Ginger Alcoholic Extract as Antiparasitic in Vitro

Details

Type

Article

Created At

15 Feb 2025