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411482

The Association between Diabetes Mellitus Type 1 and Epstein-Barr virus Infection at Serological and PCR levels

Article

Last updated: 15 Feb 2025

OverviewSimilar Items

Subjects

-

Tags

virology

Abstract

Background: Type 1 diabetes (T1D) is caused by the autoimmune system destroying pancreatic cells. Epstein-Barr virus (EBV) is a linear ds DNA virus. Most children get an early seroconversion infection with EBV and virus antibodies peak between 1-2 years of age. Objective: The aim was to detect Immunoglobulin M (IgM) and IgG antibodies against EBV in children recently diagnosed with T1D and finding the association between EBV infection and glutamic acid decarboxylase antibodies and zinc transporter 8 autoantibodies in those children. Methodology: This study included 50 children their age ranged from 1-18 years with new-onset T1D within 3 months of diagnosis and 50 controls from March to October 2022. Result: In the control group, 2% of participants had positive IgM compared to 18% of the patients' group (p = 0.008). The percentage of positive EBV IgM was significantly higher in positive (37.5%) than negative PCR patients (11.1%) (P = 0.042). Additionally, the percentage of positive GADA marker was statistically significant higher in positive (57.1%) than negative PCR patients (22.2%) (P = 0.017). Conclusion: There was significant difference as regards EBV IgM marker and GADA marker between positive and negative PCR patients.

DOI

10.21608/ejmm.2025.358732.1470

Keywords

Type 1 diabetes, Epstein-Barr virus, polymerase chain reaction, glutamic acid decarboxylase antibodies, zinc transporter 8 autoantibodies

Authors

First Name

Nehal

Last Name

Harfoush

MiddleName

M.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Damietta University, Damietta, Egypt

Email

prdt1919@hotmail.com

City

-

Orcid

-

First Name

W.

Last Name

Zaghloul

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

wafaa.saad628@gmail.com

City

Mansoura

Orcid

-

First Name

Wafaa

Last Name

Mowafy

MiddleName

K.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

wafaa.mowafy@hotmail.com

City

Mansoura

Orcid

-

First Name

Nanees

Last Name

Salem

MiddleName

A.

Affiliation

Pediatric Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

nanees.salem@gmail.com

City

Mansoura

Orcid

-

First Name

Raghdaa

Last Name

Shrief

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Damietta University, Damietta, Egypt

Email

ragnem@du.edu.eg

City

Damietta

Orcid

-

Volume

34

Article Issue

3

Related Issue

53640

Issue Date

2025-07-01

Receive Date

2025-02-06

Publish Date

2025-07-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_411482.html

Detail API

http://journals.ekb.eg?_action=service&article_code=411482

Order

411,482

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

The Association between Diabetes Mellitus Type 1 and Epstein-Barr virus Infection at Serological and PCR levels

Details

Type

Article

Created At

15 Feb 2025