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411062

Granzyme B Gene Polymorphism (rs11539752) and Breast Cancer in Egyptian Women

Article

Last updated: 15 Feb 2025

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Subjects

-

Tags

Genetics

Abstract

Background: Breast cancer (BC) is the most common type of female cancer in Egypt. Granzyme B (GrB) is primarily found in cytotoxic granules and has traditionally been considered the most abundant granzyme. However, recent research has revealed various other crucial roles for GrB. Specifically, GrB expression in both normal epithelial cells and cancer cells affects extracellular matrix remodeling, epithelial-to-mesenchymal transition, and fibrosis. Objectives: In this study, we investigated whether a common genetic variation in the gene encoding GrB, consisting of one single nucleotide polymorphisms (rs11539752), is associated with breast cancer risk in Egyptian women. Methodology: This study included 195 participants, with 103 diagnosed with breast cancer and 92 serving as controls.  Genotyping of the Granzyme B gene variants (rs11539752) was conducted using tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Results: We find that CC genotype was higher in breast cancer group than control group and GG genotype was higher in breast cancer group than control group (p>0.05) and odds ratio (95% confidence interval) in GG genotype between breast cancer and control groups 0.971 (0.939-1.004). Conclusion: The variant allele (rs11539752) couldn't be considered as a predictive factor for breast cancer development in Egyptian women.

DOI

10.21608/ejmm.2025.356093.1453

Keywords

breast cancer, SNP, Granzyme b polymorphism, Egyptian patients, case-control study

Authors

First Name

Fatma

Last Name

Osman

MiddleName

E.E.

Affiliation

Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

dr_basma_111@hotmail.com

City

-

Orcid

-

First Name

Sobhy

Last Name

Hassab El Nabi

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

drsobhyhassabelnabi@science.menofia.edu.eg

City

-

Orcid

-

First Name

Islam

Last Name

El-Garawani

MiddleName

M.

Affiliation

Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

dr.garawani@science.menofia.edu.eg

City

menofia

Orcid

-

First Name

Ehab

Last Name

Oraby

MiddleName

M.

Affiliation

General Surgery, Faculty of Medicine, Benha University, Egypt

Email

ehab.arabi@fmed.bu.edu.eg

City

-

Orcid

-

First Name

Mahmoud

Last Name

Kamel

MiddleName

M.

Affiliation

Clinical Pathology, National Cancer Institute, Cairo University, Egypt

Email

mahmoud.kamel@nci.cu.edu.eg

City

-

Orcid

-

First Name

Heba

Last Name

Hathout

MiddleName

M.R.

Affiliation

Natural Resources Department, Faculty of African Postgraduate Studies, Cairo University, Egypt

Email

hathoutheba@cu.edu.eg

City

Shebin el kom

Orcid

-

First Name

Mona

Last Name

Abo El-Ela

MiddleName

M.

Affiliation

General Surgery, Faculty of Medicine, Benha University, Egypt

Email

abuelela.mona@gmail.com

City

-

Orcid

-

Volume

34

Article Issue

3

Related Issue

53640

Issue Date

2025-07-01

Receive Date

2025-01-28

Publish Date

2025-07-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_411062.html

Detail API

http://journals.ekb.eg?_action=service&article_code=411062

Order

411,062

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Granzyme B Gene Polymorphism (rs11539752) and Breast Cancer in Egyptian Women

Details

Type

Article

Created At

15 Feb 2025