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410854

Interferon-Induced Protein-10 and Plasma Interleukin-26 in Systemic Lupus Erythematosus

Article

Last updated: 15 Feb 2025

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Tags

Diagnostics

Abstract

Background: Systemic lupus erythematosus is a chronic, immune-mediated, multifactorial illness that affects multiple systems. One cytokine that has a role in the pathophysiology of a number of inflammatory diseases is interferon-induced protein 10 (IP-10). The newest member of the IL-20 cytokine subfamily, interleukin-26 (IL-26), is a novel mediator of inflammation that is overexpressed in activated immune cells. Objective: The aim of this work was to assess the plasma levels of IL-26 and IP-10 expression in peripheral blood mononuclear cells (PBMCs) in lupus patients and healthy controls, as well as establishing a relationship between these levels and lupus activity. Methodology: Forty-five lupus patients with forty-five matched controls were included. The real-time reverse transcription-polymerase chain reaction (RT-PCR) was used to evaluate IP-10 expression levels in PBMCs, while plasma IL-26 levels were measured using the enzyme-linked immunosorbent assay (ELISA). Results: Compared to the control group, lupus patients had significantly higher levels of plasma IL-26 and PBMC expression of IP-10 (P-value < 0.001). The levels of IP-10 expression and lupus activity were shown to be significantly positively correlated (r = 0.361, P-value < 0.015). Furthermore, a significant relationship between lupus activity and IL-26 levels was observed (r = 0.573, P-value < 0.001). The levels of IL-26 and IP-10, meanwhile, showed a strong positive correlation (r = 0.619, P < 0.001). Conclusion: IP-10 and IL-26 might be useful biomarkers for lupus diagnosis and prognosis, as well as promising therapeutic targets.

DOI

10.21608/ejmm.2025.356267.1457

Keywords

Key words: Interleukin 26, Interferon-induced protein 10, Systemic lupus erythematosus

Authors

First Name

Asmaa

Last Name

Hegab

MiddleName

S.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

asmahgab@yahoo.com

City

-

Orcid

-

First Name

Nancy

Last Name

Abd Allah

MiddleName

N.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

nancynabilmicro@gmail.com

City

-

Orcid

-

First Name

Lamiaa

Last Name

Madkour

MiddleName

A.F.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

m_l@kasralainy.edu.eg

City

-

Orcid

-

First Name

Magda

Last Name

Ayoub

MiddleName

I.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

drmagdaayoub@hotmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

El-Maghraby

MiddleName

A.

Affiliation

Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

ahmedelmaghraby155@gmail.com

City

-

Orcid

-

First Name

Hanaa

Last Name

Abdel-Aty

MiddleName

F.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

hfathy2@kasralainy.edu.eg

City

-

Orcid

-

Volume

34

Article Issue

3

Related Issue

53640

Issue Date

2025-07-01

Receive Date

2025-01-28

Publish Date

2025-07-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_410854.html

Detail API

http://journals.ekb.eg?_action=service&article_code=410854

Order

410,854

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Interferon-Induced Protein-10 and Plasma Interleukin-26 in Systemic Lupus Erythematosus

Details

Type

Article

Created At

15 Feb 2025