This study assess the pomegranate's antioxidant capacity and total phenolic content and its role as antioxidant against oxidative damages and alteration in biochemical, hematological and hormonal indices and renal and liver tissues after exposure to Lambda-cyhalothrin in experimental animals. The findings indicate that DPPH (1, 1diphenyl-2-picryl hydrazyl) and ABTS radical assays produced the strongest antioxidant activity, exceeding those of KMnO4. Pomegranate peels contain 77.09g/100g total carbohydrate, 17.08g/100g total soluble sugar, 2.27g/100g total phenols and 2.04 g/100g total flavonoids. Lambdacyhalothrin had adverse effect on human and animal, since it modifies the activities of the kidneys and liver, hematological parameters and modify the organs' histological structure. Pomegranate peels improved toxicity induced by this insecticides because pomegranate peels contain high level of antioxidant compounds.