Background: Thyroid hormones T3 and T4 maintain a fine balance of glucose homeostasis by acting as insulin agonistic and antagonistic. Objective: In this study we aim to asses insulin resistance in patients who have thyroid disorders. Methods:  the current inquiry was a case-control study with 60 participants. The subjects were split into three equal groups: 20 individuals with a hypothyroidism, 20 individuals with hyperthyroidism and
20 euthyroid individuals. Gathering medical history and measure body mass index. In addition, check the thyroid gland locally. Testing for HOMA-IR, TSH, Free T3, and Free T4 .Results: There was a statistically significant moderate negative linear correlation between free T4 and HOMA-IR (r=-0.491, p=0.028) only in hypothyroid patients' group. There was a statistically significant moderate negative linear correlation between free T3 and HOMA-IR (r=-0.505, p<0.001) in all studied population, however this significant correlation lost in studying each group separately (p-values >0.05). There was a statistically significant moderate positive linear correlation between TSH and  HOMA-IR (r=0.644, p<0.001) in all studied population, however this significant correlation lost in studying each group separately (p-values >0.05). Conclusion: There is a significant association between thyroid dysfunction and HOMA-IR.