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411058

Forkhead Box p3 Gene Polymorphism in Bronchial Asthma Patients at Aswan University

Article

Last updated: 09 Apr 2025

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Subjects

-

Tags

Genetics

Abstract

Background: The lungs are impacted by diverse chronic illnesses such as asthma. Through genetic polymorphisms and epigenetic pathways, the aetiology of asthma may be connected to the changed activities of the forkhead box P3 gene (FOXP3). Objective: the aim of this research was to find whether there was any association between FOXP3 polymorphism rs2232365 and asthma and to study the effect of this polymorphism on asthma severity. Methodology: this research is a case control study of 240 Egyptian participants enlisted and divided into two groups: 120 people with asthma and 120 people were not asthmatic. Results: There was a statistically significant reduction in spirometry parameters (FVC%, FEV1%, and FEV1/FVC ratio) in the patient group relative to the control group. The serum IGE and eosinophils count were higher in cases. A statistically significant difference was observed in the various genotypes of FOXP3 polymorphism (rs2232365) and the most common genotype among the patients under investigation was the GG genotype and it was associated with higher IgE and Eosinophils (both in blood and sputum) in comparison to the AA and AG genotypes (p <0.05).Conclusion: Since the GG Genotype was the most common genotype among the patients under investigation and it was associated with higher IgE and Eosinophil (both in blood and sputum). The GG genotype of rs2232365 may act as a risk allele for bronchial asthma

DOI

10.21608/ejmm.2025.355663.1454

Keywords

(FOXP3) gene polymorphism, asthmatic cases, GG Genotype

Authors

First Name

Amal

Last Name

Ali

MiddleName

H.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Aswan University, Egypt

Email

dramalsalama2018@yahoo.com

City

-

Orcid

-

First Name

Alzahraa

Last Name

Abozeid

MiddleName

G.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Aswan University, Egypt

Email

alz.gam2000@gmail.com

City

-

Orcid

-

First Name

Islam

Last Name

Sayed

MiddleName

G.

Affiliation

Chest Department, Faculty of Medicine, Aswan University

Email

islamgalal76@yahoo.com

City

-

Orcid

0000-0003-0844-4215

First Name

Ahmed

Last Name

Ahmed

MiddleName

S.

Affiliation

3Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Egypt

Email

ahmedsadek1945@yahoo.com

City

Assiut

Orcid

-

First Name

Mohamed

Last Name

Amin

MiddleName

M.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Aswan University, Egypt

Email

mohamed.mostafa@aswu.edu.eg

City

-

Orcid

-

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2025-01-28

Publish Date

2025-04-01

Page Start

1

Page End

8

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 34_Issue 2_Pages 1-8.pdf

PDF . 519.0kB

Link

https://ejmm.journals.ekb.eg/article_411058.html

Detail API

http://journals.ekb.eg?_action=service&article_code=411058

Order

1

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Forkhead Box p3 Gene Polymorphism in Bronchial Asthma Patients at Aswan University

Details

Type

Article

Created At

15 Feb 2025