The purpose of this study was to investigate the effects of quinoa seeds on hyperlipidemic rats. Quinoa seeds have been chemically analyzed for their composition and antioxidant content. Eighteen male rats weighing (126 ± 10g) were randomly divided into three groups (6 each). The first group served as a negative control group (-ve), the second group served as an untreated hyperlipidemic group (+ve) and the third group was treated hyperlipidemic group with quinoa seeds. The experiment lasted for 60 days, during which food intake and rat's weight were recorded to get nutritious parameters. Blood samples were collected to assays some kidney and liver functions, lipid profile and Troponin T levels. Also, the histopathological examination changes in cardiac tissues and aorty of heart. The Study results showed that the untreated hyperlipidemic group (+ve) had a significant increase and imbalance in body weight gain and the levels of some kidney and liver functions, lipid profile and Troponin T when comparing to the negative control group (-ve). While, hyperlipidemic rats feed on quinoa seeds had a significant decrease and improvement in levels in body weight gain and the levels of some kidney and liver functions, lipid profile and Troponin T comparing to untreated hyperlipidemic group (+ve) Also, the histopathological examination of heart tissues and aorty specimens showed positive effect in hyperlipidemic group treated with quinoa seeds. We recommend consuming quinoa seeds with diets because they play a significantly role in the treatment of hyperlipidemia.