Background: Systemic lupus erythematosus (SLE), an autoimmune illness, with severe inflammatory signs. Skin, neurological, central nervous system, and hematological involvement are common. Objectives: This study aimed to assess gastrointestinal (GIT) proof and superior endoscopic outcomes in SLE cases. Methods: According to the 1997 American College of Rheumatology (ACR) revised categorization tests, 40 SLE cases, aged 18 and older, of either gender, and accompanied by two people of the same gender, participated in a cross-localized ER study. Laboratory investigations, including thorough ancestry pictures, liver and kidney function tests, lipid sketches, cells with hemoglobin sedimentation rate, C-reactive protein, complements, antagonistic-dsDNA, and a full excretion study, were performed on all patients. Comprehensive abdominal ultrasonography was performed on all cases, and esophagogastroduodenoscopy (EGD) was performed on selected prisoners. Result: Regarding the dispassionate symptoms of GIT proofs, 8 (42.11%) inmates believed that things would go badly, 7 (36.84%) were gaunt, 6 (31.58%) inmates experienced abdominal pain, 3 (15.79%) experienced bloating, 3 (15.79%) experienced loose bowels, 3 (15.79%) experienced nausea or disgorging, 3 (15.79%) experienced burden loss, and 1 (5.26%) experienced constipation. Conclusions: The doctors see the GI symptoms of SLE since early detection and the right circumstances can affect the patients' prognosis. In our investigation, EGD demonstrated saddening symptoms that are indicative of SLE.