Abstract: Background: Entrepreneurial leadership is becoming concept in health that can affect and direct performance and achievement of either staff or organizations goals. Entrepreneurial leadership and innovative work behavior are widely regarded as an important basis for competitive advantage in work environment and enhancing capabilities for work growth and the wealth of nations. Purpose: To assess the relation between entrepreneurial leadership and innovative work behavior among nurses at Menoufia University Hospital. Design: A correlational research design was used. Setting: The study was conducted at Menoufia University Hospital. Subjects: A convenient sampling of 300 nurses constitutes the study sample. Two instruments were used which are entrepreneurial leadership questionnaire and innovative work behavior scale. Results: showed that More than half (59.7%) of studied nurses had high level of entrepreneurial leadership and more than two fifth (46%) of them had high level of innovative work behavior while, the minority (6.3% ,16%) of them had low level of both entrepreneurial leadership and innovative work behavior respectively. Conclusion: There was a highly statistically significant positive strong correlation between entrepreneurial leadership and innovative work behavior among studied nurses. Recommendations: Conduct training program for nurses to enhance their knowledge and skills related to entrepreneurial leadership and innovative work behavior. Further study about barriers affecting entrepreneurial leadership and innovative work behavior in different health care sectors.