Background: Refugees are at particularly high risk of developing Tuberculosis which is a persistent problem in many developmental countries; and that is no doubt that disease has a serious impact on performance and quality of life among refugees with tuberculosis. Aim: The aim of this study was to assess quality of life among African refugees with tuberculosis in Greater Cairo. Design: A descriptive design used to conduct this study. Setting: The study was conducted in two setting; at outpatient clinics of Abbassia Chest Diseases Hospital and Refuge Egypt TB clinics in Zamalek which is a non-governmental organization. Sample: A purposive sample of 240 of African refugees were included in this study which selected as recently diagnosed with confirmed tuberculosis in last six month and their age between 18 to 45 years. Tools: The data were collected using a self-administered questionnaire form which consisted of 6 parts to assess socio-demographic data for African refugees, their medical history, knowledge, attitude, and practices towards prevention of Tuberculosis and refugee's quality of life scale. Results: The study result shows that 52.5% of the studied refugees were males, and 47.5% females, 45.4% of had poor knowledge, 34.2% of had negative attitude, and 77.1% of them had inadequate level of practices about prevention of tuberculosis. Also 46.2% of study sample of African Refugees suffered from low level of quality of life related to physical domain and 65% to psychological domain also 55.8% to social relationships and 52.1% to environmental domain while 33.4% of them suffer from low level of total quality of life. Conclusion: There was a statistically significant relation between quality of life and refugees' educational level, home crowding index, their knowledge about tuberculosis. While insignificant statistical relation with their attitude and practices toward prevention of tuberculosis with p value ˃0.05. Recommendations: Designing and implementing of educational program for African refugees to increase awareness, knowledge, practices, and attitude regarding TB disease.