Two experiments were conducted to determine the nematicidal activity of jojoba oil, potassium silicate and Bio-Nematon (a commercial product of Paecilomyces lilacinus) singly or integrated against root-knot nematode, Meloidogyne incognita in vitro, and in vivo. All treatments recorded a significant increase (P≤0.05) in the mortality rate of M. incognita juveniles depending on the type of treatments and duration of exposure. The triple treatment recorded the best results, followed by the double treatment, and finally the individual treatments. The triple treatment of jojoba oil with potassium silicate and the nematicide oxamyl achieved the best results among all tested treatments with values of 113.60, 147.18, and 105.20% for plant height, plant weight, and dry weight of the vegetative mass, respectively as well as achieved the best results among all treatments in reducing the tested nematode metrics with values of 81.85, 82.59 and 82.86%, for nematode juveniles, galls, and egg masses counts, respectively. Similarly, there was a significant increase in the concentrations of nitrogen, phosphorus, potassium, and total phenolic compounds by tri-treatment, with values of 2.47, 0.556, 2.90, and 30.57%, respectively, alongside a low total chlorophyll content in the leaves of tomato plant was recovered.