: Irrigating with saline water helps mitigate the scarcity of agricultural freshwater resources, particularly in arid regions. Yeasts rapidly colonize plant surfaces, use nutrients from many sources, survive in a relatively wide range of temperatures, produce no harmful metabolites and have no harmful effects on the final food product. Algae extracts contain a series of bioactive compounds and signaling molecules, as well as mineral and organic nutrients, and thus algae extracts can be used as plant bio-stimulants due to their ability to promote plant growth in suboptimal conditions such as saline environments. In this context, the present study aims to evaluate the foliar application of yeast extract and spirulina algae alone or in combination, as a strategy, to mitigate the salinity adverse effects on tomato (Solanum Lycopersicon) plant growth. Growth. The factorial experiment was conducted in a randomized complete blocks design, consisting of four levels of water salinity (0, 1000, 2000, and 4000 mg/L of water) and one dose of yeast extract and Spirulina platensis extract (2 g yeast/L, 100 mg/L water, respectively). In general, the results showed an increase in proline and antioxidant enzymesperoxidase and polyphenol oxidase, meanwhile a decrease in protein and photosynthetic pigments in plants under salt stress. On the other hand, an increase in the studied traits has been observed when treated with yeast and spirulina while the treatment with yeast has shown a decrease in proline concentration. The use of foliar spray with yeast and Spirulina platensis made tomato plants tolerant to salt stress and reduced its negative impact. The results suggest decisive roles of yeast and Spirulina platensis extract in the management of salt-induced adverse effects in economically important tomatoes.