Spinal tuberculosis accounts for more than 50% of musculoskeletal tuberculosis and mainly involves the dorsal and dorsolumbar regions. Involvement of the lumbosacral region in spinal tuberculosis is rare, with only few reported cases in the literature. The patient may present with pain and minimal neurological deficits. Conservative management is the primary treatment modality with good outcome; surgical intervention is reserved for selected group of patients. In the present article we report an uncommon case of lumbosacral tuberculosis that was treated successfully and review the relevant literature.