Background and objectives: Double primary malignancies is challenging in management. Incidence of double primaries is increasing overtime. This study aims to review clinical, pathologic and treatment outcomes of our observed cases with double primary tumors. Our primary objective was to measure the frequency of double primary either synchronous or metachronous and the secondary objective was to identify demographical data, histopathological types, survival and treatment used in cases presented at Clinical Oncology Department in Helwan University hospital, Eldoah Hospital and Health Insurance Hospital from January 2012 till August 2022. Methods: The study included Fifty-three cancer patients treated in our centers. Prospective data of patients were retrospectively analyzed. Data analysis was done using Statistical package for Social Science (SPSS 25.0.1 for windows; SPSS Inc, Chicago, IL, 2001). Kolmogorov–Smirnov's test was used to evaluate normal distribution of continuous data, Quantitative non-parametric variables were expressed as mean and SD, Median and Interquartile range (IQR) according to the distribution of data. Qualitative variables were expressed as frequencies and percent. Survival rates were estimated and graphed using the Kaplan-Meier method. Results: Twenty four case (45.3%) were males, 29 (54.7 %) were females. Ten cases (18.9%) were synchronous and 43 case (81.1%) were metachronous. Commonest site of first tumor was breast (32.1%) followed by kidney and prostate each represented 7.5%. Most common site of second malignant tumor was colon (17%) of cases followed by lung (11.3%). Breast cancer cases represents the most common malignant tumor in19 case (35.8%) where in 17 case (32.1%) was the primary malignancy and in 2 cases was the second malignancy. Most common second diagnoses with breast was thyroid (4 cases) followed by colon (3 cases). Median overall survival from first diagnosis was 41 months and 12 months from the second diagnosis. Conclusion: Diagnosis of malignancy increases risk of second malignancies due to multiple etiologic factors. Proper follow up of cancer patients enables early diagnosis of second malignancy, improves cure rate and survival. Meticulous reporting of data of double primaries could identify screening strategies for patients at high risk.