Objective: This study aimed to compare the levels of CRP, ferritin, D-dimer, IgG, IgM, Subfatin, Asprosin, and NT Pro-BNP in four groups: control, heart failure, heart failure with corona, and heart failure after recovery from corona. Materials and Methods: Patients from 1st July 2021 until 4^th January 2022 were carried on in the isolation wards in Balad Ruz General Hospital and Baqubah Teaching Hospital/Diyala Province/IRAQ, with 89 Participants enrolled in the study, the patients were diagnosed according to the World Health Organization (WHO) guidance for COVID-19. This study included 4 groups as follows: Group 1(G1): Healthy individual, their number 20, Group 2(G2): heart failure patients, their number 25, Group 3(G3): heart failure patients with covid-19, their number 25. Group 4(G4): heart failure patients after recovery from COVID-19, for group 3 and 6 patients died with coronavirus, their number 19. Results: The result showed significant differences in the levels of IgG, IgM, Ferritin, D-dimer, and CRP which highly increased in G3 and decreased in G4. As for ferritin, it increased in heart G3, at a p-value <0.001. This study also showed decreased levels of Subfatin in G2 and G4, with an increase in G3. As for asprosin increased in G2, G3, and G4 compared with G1.NT Pro-BNP highly increased in G3, followed by G4, then G2 as compared with G1(67.19±18.44) at p-value <0.01.