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410397

Oxidative Stress, Hyperglycemia, Hyperlipidemia, and Hemostasis Impairment as Risk Factors for Diabetes in Rats: Investigating the Therapeutic Potential of Samwa (Cleome droserif

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Last updated: 15 Feb 2025

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Tags

Food Science and technology

Abstract

The current study aimed to investigate the potential efficacy of Samwa (Cleome droserifolia) ethanolic extract of as a hypoglycemic, hypolipidemic, and antioxidant agent, as well as its role in enhancing hemostatic effects in alloxan-induced diabetic rats, a model for type II diabetes. A total of 36 rats were allocated into two main groups: the first group (Group 1, 6 rats), serving as the normal control, was maintained on a basal diet (BD), while the second group (30 rats) was used for the induction of type 2 diabetes and further subdivided into five equal subgroups. These subgroups were as follows: {Group 2: Diabetic rats fed solely on BD (positive control). Groups 3–6: Diabetic rats fed on BD and administered Samwa ethanolic extract (SEE) at doses of 100, 200, 300, and 400 mg/kg body weight per day, respectively, for 28 days}. Induction of diabetes with alloxan caused a significant increase (p ≤ 0.05) in serum glucose, triglycerides, total cholesterol, LDL-c, malondialdehyde (MDA), hydrogen peroxide (H₂O₂), and leptin levels, with respective increases of 236.12%, 100.00%, 44.44%, 34.69%, 60.06%, 69.20%, and 67.40% compared to the normal control group. In contrast, HDL-c, paraoxonase, and arylesterase activities decreased by 42.65%, 51.04%, and 34.52%, respectively. Additionally, hemostatic parameters, including bleeding and clotting times, were prolonged at multiple time points (7, 14, 21, and 28 days). Treatment with SEE for 28 days significantly ameliorated these parameters in a dose-dependent manner. Improvements included reductions in glucose, lipid profiles, oxidative stress markers, and normalization of hemostatic parameters. These findings suggest that SEE has therapeutic potential in managing type 2 diabetes and its associated complications. Consequently, the incorporation of SEE into pharmacological formulations is recommended for individuals with type 2 diabetes.

DOI

10.21608/asejaiqjsae.2025.410397

Keywords

Liver functions, leptin, Insulin, malonaldehyde, Paraoxonase, arylesterase, bleeding and clotting times

Authors

First Name

Neveen

Last Name

Ismail

MiddleName

Suofy

Affiliation

Nutrition and Food Science Department Faculty of Home Economics Helwan University

Email

janatorky2012@gmail.com

City

-

Orcid

-

First Name

Yousif

Last Name

A. Elhassaneen

MiddleName

-

Affiliation

Department of Nutrition and Food Science, Faculty of Home Economics, Menoufia University, Shebin El-Kom, Egypt.

Email

-

City

-

Orcid

-

First Name

Doaa

Last Name

O. Gouda

MiddleName

-

Affiliation

Department of Home Economics, Faculty of Specific Education, Sohag University, Sohag, Egypt.

Email

-

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

52830

Issue Date

2025-03-01

Receive Date

2025-01-01

Publish Date

2025-03-01

Page Start

57

Page End

80

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 46_Issue 1_Pages 57-80.pdf

PDF . 834.3kB

Link

https://asejaiqjsae.journals.ekb.eg/article_410397.html

Detail API

http://journals.ekb.eg?_action=service&article_code=410397

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Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Oxidative Stress, Hyperglycemia, Hyperlipidemia, and Hemostasis Impairment as Risk Factors for Diabetes in Rats: Investigating the Therapeutic Potential of Samwa (Cleome droserif

Details

Type

Article

Created At

08 Feb 2025