The Amur snakehead (Channa argus) was accidentally brought to the territory of Uzbekistan in the 1960s, and now it is widespread in all water bodies of the republic from sea level to 800 meters. The current article presents the results of research on the molecular genetic analysis of Channa argus caught from the middle reaches of the Kashkadarya River. In the current study, Channa argus species was located in the phylogenetic tree with Channa bankanensis, which is distributed in the territory of Indonesia, on adjacent branches and combined to form a 95% bootstrap. The genetic distance between them was 18.4%. The nucleotide sequence of this species was included in the Genbank and accession numbers were obtained.