Abstract: Introduction: Enhancing risk management is crucial for cultivating a strong safety culture among nurses. It improves patient care while promoting the well-being of nursing staff, ultimately contributing to a more efficient and robust healthcare system. Aim: Assess the relationship between nurses' risk management and safety culture. Study design: descriptive correlational research design was used. Setting: The study was conducted at Main Hospital Assiut University at (General Internal Medicine & General Surgical) Units. Subject and Method: The study subject consists of 42 nurses. The data collected through First tool; Structured self-administered questionnaire sheet including:-a): Personal data sheet. b): AGRASS Questionnaire (Accept Group, Reduce, Avoid, Share, and Select the risk) to assess the risk management in health care setting. Second tool; questionnaire for Hospital Survey on Patient Safety Culture (HSOPSC) to assess levels of safety culture by nurses. Results: The majority of nurses had unsatisfactory risk management score and more than half of them had low safety culture level (83.3% & 57.1%) respectively. Conclusion: There were statistical significant relationship between risk management and safety culture (0.014*) .Recommendation: Develop and implement continues educational programs and seminars on risk management and safety culture for nurses.