The aim of this research was to identify the best tomato (Solanum lycopersicum L.) genotypes for hybrids production under Egyptian desert conditions. The tomato genotypes (6 parents and their 15 crosses) were evaluated in season 2023/2024 at two locations. The first was Ras-Sudr station, Desert Research Center (DRC), South Sinai; the second was Alsaalihia zone, El-Sharkia governorate. The experimental design was randomized complete block design with three replicates. The results indicated that the mean squares due to genotypes were highly significant for all studied traits in both locations. GCA was larger than SCA for most studied traits, this indicate that additive gene effects were more important than non-additive gene effects in the inheritance of these traits under the two locations. P1 line had the greatest GCA effects for most traits followed by P5 line and then P6 line. Cross P5× P6 had positive and highly significant values of SCA effects for yield per plant, in the two locations. The high salinity of the irrigation water in the first location led to a decrease in yield per plant by 28.13 and 30.56% for the average of the parents and hybrids, respectively, compared to the second location, which was irrigated with low salinity irrigation water. Therefore, when planting the land affected with salinity, choosing prefers tomato hybrids with high productivity under these lands.